The water solubility of II-10c, II-10h and III-15h.
| Compound | log Pa | pH = 7.0b (μg mL−1) | pH = 7.4b (μg mL−1) | pH = 2.0b (μg mL−1) | |||
|---|---|---|---|---|---|---|---|
| 1c | 2d | 1c | 2d | 1c | 2d | ||
| PF-74 | 1.96 | 7.85 | 7.84 | 9.30 | 9.37 | 17.96 | 18.01 |
| II-10c | 2.29 | 4.02 | 4.09 | 3.92 | 3.89 | 9.29 | 9.35 |
| II-10h | 2.07 | 2.71 | 2.69 | 2.66 | 2.73 | 5.05 | 5.14 |
| III-15h | 2.36 | 3.23 | 3.29 | 3.01 | 3.10 | 5.94 | 5.85 |
a
log P: logarithm of partition coefficient, measured by HPLC.
b
Measured in phosphate buffer by HPLC method in duplicate.
c
Data from the first test.
d
Data from the second test.