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. 2020 Feb 17;13:1431–1445. doi: 10.2147/OTT.S227831

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© 2020 Ding et al.

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Role of CCAT2 and miR-424 in regulating chemosensitivity of glioma cells. (A) CCAT2 and miR-424 expressions were determined within glioma cells (i.e., U251, U87, A172 and SHG44) and NHA cells. *: P<0.05 when compared with NHA cells. (B) The inhibition rates were evaluated within glioma cells (i.e., U251, U87, A172 and SHG44) after the treatment of Teniposide, Temozolomide, Vincristine and Cisplatin. (C) CCAT2 expression was detected in SHG44 and U251 cells after the transfection of NC, pcDNA3.1, pcDNA3.1-CCAT2, si-RNA, si-CCAT2-1 and si-CCAT2-2. *: P<0.05 when compared with the NC group. (D) Expression of miR-424 in SHG44 and U251 cells was drawn when NC, miR mimic, miR-424 mimic, miR inhibitor and miR-424 inhibitor were transfected. *: P<0.05 when compared with the NC group. Survival of glioma cells was compared after treatment of chemo drugs and transfections of (E) pcDNA3.1-CCAT2/si-CCAT2-2 or (F) miR-424 mimic/miR-424 inhibitor. *: P<0.05 when compared with the NC group.