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. 2020 Feb 17;13:1431–1445. doi: 10.2147/OTT.S227831

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© 2020 Ding et al.

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CHK1 mediated the role of miR-424 in affecting viability, proliferation and apoptosis of glioma cells. (A) The amount of CHK1 in SHG44 and U251 cells was verified after transfection of pcDNA3.1-CHK1. *: P<0.05 when compared with the NC group. (B) The viability of glioma cells was drawn among NC, miR-mimic, miR-424 mimic and miR-424 mimic+pcDNA3.1-CHK1 groups. *: P<0.05 when compared with the NC group. (C) The proliferative capacity of glioma cells was compared among NC, miR-mimic, miR-424 mimic and miR-424 mimic+pcDNA3.1-CHK1 groups. *: P<0.05 when compared with the NC group. (D) The apoptotic percentage of glioma cells was observed after respective treatments of NC, miR-mimic, miR-424 mimic and miR-424 mimic+pcDNA3.1-CHK1 groups. *: P<0.05 when compared with the NC group.