Table 3.
Arterial Blood Gases During Pharmacologically Induced Pulmonary Hypertension
| pH | pCO2 (kPa) | pO2 (kPa) | Hb (g L−1) | |
|---|---|---|---|---|
| iNO (ppm) | ||||
| Baseline | 7.53 (7.49–7.60) | 4.9 (4.5–5.0) | 13.4 (12.0–13.4) | 80 (75–80) |
| U46619 | 7.52 (7.48–7.56) | 4.5 (4.3–4.7) | 12.1 (9.9–13.4) | 80 (76–84) |
| U46619 + iNO 5 | 7.53 (7.51–7.57)b | 4.2 (4.1–4.5) | 13.7 (12.0–14.6)b | 80 (75–84) |
| U46619 + iNO 10 | 7.53 (7.51–7.58)b | 4.1 (3.9–4.5) | 12.8 (12.0–14.7)b | 80 (76–84) |
| U46619 + iNO 20 | 7.54 (7.51–7.57)b | 4.2 (3.9–4.5) | 13.0 (12.4–14.5)b | 79 (76–85) |
| U46619 + iNO 40 | 7.54 (7.51–7.58)b | 4.2 (4.1–4.5) | 12.9 (12.4–15.0)b | 79 (71–85) |
| PDNO (nmol kg−1 min−1) | ||||
| Baseline | 7.56 (7.49–7.57) | 4.5 (4.4–4.9) | 13.9 (11.7–14.1) | 74 (70–76) |
| U46619 | 7.52 (7.47–7.55) | 4.4 (4.2–4.8) | 11.3 (9.4–13.0)a | 79 (73–82)a |
| U46619 + PDNO 15 | 7.55 (7.48–7.57) | 4.3 (4.1–4.8) | 11.8 (11.0–11.9) | 76 (74–76) |
| U46619 + PDNO 30 | 7.57 (7.48–7.59)b | 4.2 (3.9–4.7) | 12.6 (11.8–13.6)b | 75 (70–84) |
| U46619 + PDNO 45 | 7.56 (7.48–7.59)b | 4.2 (3.9–4.7) | 12.8 (12.3–14.0)b | 74 (69–81) |
| U46619 + PDNO 60 | 7.56 (7.49–7.60)b | 4.2 (4.1–4.7) | 12.6 (12.1–14.0)b | 74 (69–77) |
Notes: Arterial blood gases at baseline, at U46619 administration (60–150 ng kg−1 min−1), after 7–10 mins of four doses of 1,2-propanediol mono-organic nitrites infusion (PDNO, n=6) and after 7–10 mins of four fractions of inhaled nitric oxide (iNO, n=7) in anesthetized pigs. aIndicates statistical difference from baseline to U46619. bRepresents statistical difference from U46619 to each dose. No statistical analysis was performed on PDNO 15 nmol kg−1 min−1, due to only three observations caused by syringe pump problems. Data are median and interquartile ranges (IQR).
Abbreviations: pCO2, arterial partial pressure of carbon dioxide; pO2, arterial partial pressure of oxygen; Hb, hemoglobin.