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. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Adv Exp Med Biol. 2019;1124:3–46. doi: 10.1007/978-981-13-5895-1_1

Fig. 1.2.

Fig. 1.2

Simultaneous recording from ICC-MY and SMC. Recording from ICC-MY and SMCs simultaneously shows that the upstroke of slow waves originates in ICC-MY and conducts with decrement to electrically coupled SMCs. The conductances present in SMCs cannot support active propagation of slow waves in these cells; however, the depolarization can activate other voltage-dependent conductances that support contractions (L-type Ca2+ channels and shape the slow wave; various voltage-dependent K+ channels). The peak of the slow wave reaches about −10 mV (approximately the equilibrium potential for Cl− ions) and is relatively constant for durations of a second or more. Anatomical drawing depicts circular (CM) and longitudinal (LM) muscle layers, ICC-MY in a network between CM and LM, and ICC-IM, lying in close apposition to an enteric motor neurons (gray varicose process). Redrawn from [2], and original data was provided by Professor David Hirst