Fig. 1.8.

Loss of slow waves in small intestinal and gastric muscles in Ano1^−/− mice. (a) Genotypes of Ano1^−/− mice. The wild-type allele was absent in animals 1–3 in this litter, demonstrating that these animals were Ano1^−/−. Animal 4 was a heterozygote and animal 5 was a wild-type homozygote. (b, c) Electrical recording from jejunal and antral circular muscles from each animal with intracellular electrodes. Slow waves were absent in Ano1^−/− mice, and normal in animals with wild-type alleles. (d, e) ICC-MY (arrows) and ICC-DMP (arrowheads), with an apparently normal distribution and density, were present in tissues of Ano1^−/− mice (small intestine shown). Scale bar for d and e is shown in e. Figure is redrawn from [206] with permission