Figure 2.

Effects of unilateral dopamine depletion by 6-OHDA and repeated L-DOPA treatment on gene expression in the striatum. Mean density values (mean ± SEM) for 5-HT1B, 5-HT2C, dynorphin (DYN), and enkephalin (ENK) in rats with sham/partial lesions (S/V), rats with a 6-OHDA lesion only (6/V), and rats with a dopamine lesion followed by repeated L-DOPA treatment (6/L-DOPA) are given for the medial (m), dorsal (d), and dorsolateral (dl) sectors on the side ipsilateral (LESION) and contralateral (INTACT) to the lesion, on the middle striatal level (see Fig. 3 for locations of these sectors). In contrast to the robust changes in gene expression for 5-HT1B, dynorphin and enkephalin, no changes were found for 5-HT2C. *p<0.05, **p<0.01, ***p<0.001 vs. S/V or as indicated; ^#p<0.05, ^##p<0.01, ^###p<0.001 vs. same group on intact side.