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. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Mol Neurobiol. 2019 Aug 29;57(2):736–751. doi: 10.1007/s12035-019-01739-x

Figure 7.

Figure 7.

Relationship between L-DOPA-induced dyskinesias (AIMs) and increases in gene expression in the striatum. The scatter plot shows the relationship between the r values for gene expression x AIMs (total AIMs, 3-day averages, week 3) correlations for 5-HT1B expression and those for dynorphin expression, in the 23 striatal sectors of the 6/L-DOPA group [r=0.451, p<0.05; without outlier (C/m), r=0.575, p<0.005]. The broken lines indicate the significance threshold for the single-sector correlations (r=0.67, p=0.05). Note that 5 of the 10 associative sectors (red dots) showed significant positive correlations between 5-HT1B expression and total AIMs scores (r>0.67, p<0.05), and 2 of the 10 associative sectors showed significant positive correlations between dynorphin expression and total AIMs scores. In contrast, none of the 8 sensorimotor sectors (dark blue dots) or 5 limbic sectors (light gray dots) displayed significant gene expression x AIMs correlations (r<0.67, p>0.05). R/lC, rostral/lateral core; R/v, rostral/ventral; M/c, middle/central; M/m, middle/medial; M/v, middle/ventral; C/dc, caudal/dorsal central; C/m, caudal/medial; C/v, caudal/ventral. *p<0.05.

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