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. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Mol Neurobiol. 2019 Aug 29;57(2):736–751. doi: 10.1007/s12035-019-01739-x

Figure 8.

Figure 8.

Regional expression of 5-HT1B in the dopamine-depleted striatum and its relationship to L-DOPA-induced dyskinesias (total AIMs) in 6/L-DOPA group. (Top) Expression of 5-HT1B (mean density, mean ± SEM, in % of intact side) in total rostral (R), middle (M) and caudal (C) striatum (left), and in averaged limbic (LI), associative (AS) and sensorimotor (SM) sectors, on the side of the lesion is depicted. (Bottom) Scatter plots show the relationship between the total AIMs scores (3-day averages, week 3) and the increases in 5-HT1B expression in averaged limbic, associative or sensorimotor sectors on the rostral and middle striatal levels for individual animals of the 6/L-DOPA group. There was a significant positive correlation for total AIMs vs. increases in 5-HT1B expression in the associative striatum on the middle level (r=0.893, p<0.01). *p<0.05, **p<0.01, ***p<0.001.