Table 1.

Studies regarding agricultural occupational pesticide exposure and cancer: May 15, 2018 – May 14, 2019

Author	Participants	Exposures and Assessments	Outcomes and Assessments	Key Results (all confidence intervals at 95%)
Cancer
Lerro CC et al. April 2019 [19]	Agricultural Health Study (AHS): 89,565 private and commercial pesticide applicators and spouses, from North Carolina and Iowa, recruited from 1993 to 1997	Self-administered questionnaires on farm life & agricultural practices, types of crops & livestock, pesticide use/use of >50 individual pesticide active ingredients	Incident cancer cases from NC and IA state cancer registries	All cancer sites: SIR (private applicators)=0.91, CI 0.89 – 0.93 SIR (commercial applicators) =0.83, CI 0.76 – 0.92 Lip cancer: SIR (private applicators)=2.22, CI 1.71 – 2.84 Prostate cancer: SIR (private applicators)=1.15, CI 1.11 – 1.19 B-cell lymphomas overall: SIR (private applicators)=1.12, CI 1.03 – 1.21 Chronic lymphocytic leukemia: SIR (private applicators)=1.17, CI 1.00 – 1.36 Acute myeloid leukemia: SIR (private applicators)=1.29, CI 1.03 – 1.59
Leon ME et al. March 2019 [20]	Subset of the Agricultural Health Study (AHS), including: 57,310 private and commercial pesticide applicators from North Carolina and Iowa, recruited from 1993 to 1997 Agriculture and Cancer (AGRICAN): 181,747 active and retired farm workers in France, recruited from 2005–2007 Subset of the Cancer in the Norwegian Agricultural Population (CNAP), including: 147,134 farm holders in Norway, based on censuses in 1969, 1974, 1979, 1985, 1989	AHS: self-administered enrollment questionnaires on farm life & agricultural practices, types of crops & livestock, pesticide use/use of >50 individual pesticide active ingredients, 5 year follow-up questionnaires on pesticide use since enrollment AGRICAN: self-administered questionnaires on cultivating 13 crops and raising 5 animal species and performance of pesticide treatment tasks, crossed with country-specific-crop-exposure matrices CNAP: census data on type of crops and livestock produced the preceding year, acreage, technology, pesticide expenses and pesticide spraying equipment, crossed with country-specific-crop-exposure-matrices	First incident non-Hodgkin’s lymphoma (NHL) during follow-up: AHS: North Carolina and Iowa cancer and mortality registries and the National Death Index AGRICAN: French cancer and mortality registries and the National Death Index CNAP: National Cancer Registry of Norway	NHL overall & ever use of terbufos: mHR(AGRICAN and AHS)=1.18, CI 1.00 – 1.39; Chronic lymphocytic leukemia/small lymphocytic lymphoma & ever use of deltamethrin: mHR (AGRICAN and CNAP)=1.48, CI 1.06 – 2.07 Diffuse large B-cell lymphoma & ever use of glyphosate: mHR=1.36, CI 1.00 – 1.85
Andreotti G et al. May 2018 [23]	Subset of the Agricultural Health Study (AHS): 54,251 pesticide applicators from North Carolina and Iowa, recruited from 1993–1997, 63% of whom participated in a follow up phone interview 5 years after enrollment	Ever/never use, lifetime days of use (days per year × number of years), and intensity-weighted lifetime days (lifetime days × intensity score) use of glyphosate from questionnaires at enrollment and follow-up	Incident cancer cases from North Carolina and Iowa state cancer registries	Highest quartile of glyphosate exposure to no exposure: Total cancer: RR=0.99, CI 0.91 – 1.08 Hematopoietic or lymphatic malignancies: RR=1.00, CI 0.74 – 1.34 Non-Hodgkin lymphoma: RR=0.87, CI 0.64 – 1.20 Multiple myeloma: RR=0.87, CI 0.45 – 1.69
Lerro CC et al. Sept 2018 [25]	Subset of the Agricultural Health Study (AHS): 49,685 pesticide applicators from North Carolina and Iowa, recruited from 19931997, 63% of whom participated in a follow up phone interview 5 years after enrollment	Cumulative lifetime days (sum of days of alachlor use reported at enrollment through the year last farmed reported at follow-up) and intensity-weighted days (cumulative lifetime days multiplied by an intensity-weighting factor) from questionnaires at enrollment and follow-up on alachlor use	Incident cancer cases from North Carolina and Iowa state cancer registries	Laryngeal cancer & alachlor exposure: RR (Quartile 2, 661–1762 intensity-weighted days compared to no exposure)=4.68, CI 1.95 – 11.23 RR (Quartile 3, 1763–5075 intensity-weighted days compared to no exposure)=6.04, CI 2.44 – 14.99 RR (Quartile 4, >5075 intensity-weighted days compared to no exposure)=7.10, 2.58 – 19.53
Boulanger M et al. May 2018 [27]	Agriculture and Cancer (AGRICAN): 148,044 active and retired farm workers in France, recruited from 2005–2007	Self-administered questionnaires on lifetime history of agricultural activities, cultivating 13 crops and raising 5 animal species, performance of harvesting, pesticide application, seed treatment, seedling, and/or re-entry tasks	Incident lung cancer cases from French cancer registries	Adenocarcinomas & winegrowing: HR (Ever vineyard farm work to never vineyard farm work)=1.27, CI 0.94 – 1.72 Small cell lung cancers & pea/field beans: HR (Ever pesticide application to never pesticide application)=2.38, CI 1.07 – 5.28 Squamous cell carcinomas & beets: HR (Ever pesticide application to never pesticide application)=1.47, CI 0.92 – 2.34 Squamous cell carcinomas & sunflowers: HR (Ever harvester to never harvester)=1.61, CI 0.91 – 2.86 Squamous cell carcinomas & fruit-trees: HR (Ever pruner to never pruner)=1.44, CI 0.92 – 2.27 Overall lung cancer & corn: HR (Ever grower to never grower)=0.76, CI 0.62 – 0.92 Overall lung cancer & wheat/barley: HR (Ever grower to never grower)=0.85, CI 0.70 – 1.04
Peil C et al. November 2018 [28]	Agriculture and Cancer (AGRICAN): 181,842 active and retired farm workers in France, recruited from 2005–2007	Self-administered questionnaires on cultivating 13 crops and raising 5 animal species and occupational activities	Incident central nervous system cancer cases (gliomas and meningiomas) from French cancer registries and the National Death Index	CNS tumors & exposure to all carbamates: HR=1.47, CI 1.03 – 2.10