Table 2.
Summary of cryo-EM structures from flavivirus-antibody complexes.
| Virus name | Antigen | Antibodya | Fragment | EMD codes | Resolution (Å) |
|---|---|---|---|---|---|
| Dengue virus (DENV) | DENV1 mature virion | 14c10 | Fab | 5268 | 7 |
| 1F4 | Fab | 2442 | 6 | ||
| DENV2 mature virion | 747(4)B7 | Fab | 2818 | 10.24 | |
| 1A1D-2 | Fab | 1418 | 24 | ||
| 2D22 | Fab | 2967/2968/2969/2996/2997/2998/2999 | 6.5/20/21/6.9/13/11/23 | ||
| DENV2 immature virion | 2H2 | Fab | 5674/5675/5676/5677 | 21/25/21/21 | |
| E53 | Fab | 5102 | 23 | ||
| DENV3 immature virion | 1H10 | Fab | 9649/9650/9651 | 12/25/25 | |
| DENV3 mature virion | 5J7 | Fab | 5935 | 9 | |
| West Nile Virus (WNV) | Immature virion | E53 | Fab | 5103 | 15 |
| Mature virion | E16 | Fab | 1234 | 14.5 | |
| E16 | scFv | 5115 | 22.75 | ||
| CR4354 | Fab | 5190 | 13.7 | ||
| Tick-borne encephalitis virus (TBEV) | Mature virion | 19/1786 | Fab | 3754/3755 | 3.9/19.2 |
| Zika virus (ZIKV) | Mature virion | ZIKV-117 | Fab | 8548 | 6.2 |
| ZKA190 | Fab | 6793/6794 | 22/22 | ||
| Z23 | Fab | 9542 | 9.4 | ||
| C10 | Fab | 9573/9574/9575 | 4.4/12/4 | ||
| ZAb-FLEP | Fab | 7613 | 9.7 | ||
| ZK2B10 | Fab | 9811/9812 | 20/11 | ||
| ZIKV-195 | Fab | 9131 | 4 | ||
| Japanese encephalitis virus (JEV) | Mature virion | 2F2 | Fab | 6854 | 4.7 |
| 2H4 | Fab | 6855 | 4.6 |
aThe possible neutralization mechanisms for flavivirus antibodies discussed in the text are summarized below. 14c10: blocking receptor binding (Teoh et al.2012), 1F4: blocking virus attachment (Fibriansah et al.2014), 1A1D-2: blocking virus attachment by binding to hidden epitopes (Lok et al.2008), 2D22: blocking capsid reorganization required for virus fusion (Fibriansah et al.2015a), 2H2: inhibition of virus maturation (Wang et al.2013), E53: binding to partially immature heterogeneous virions (Cherrier et al.2009), 1H10: enhancing immature virus attachment to endosomal membrane (Wirawan et al.2019), 5J7: blocking receptor binding and capsid stabilization (Fibriansah et al.2015b), E16: blocking capsid reorganization required for virus fusion (Kaufmann et al.2006), ZIKV-117: capsid stabilization (Hasan et al.2017), ZKA190: inhibition of either cell attachment or membrane fusion (Wang J et al.2017), C10: capsid stabilization (Zhang et al.2016).