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. 2020 Feb 21;10:3199. doi: 10.1038/s41598-020-60246-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose and LET_d distributions from a single flat SOBP and a downslope SOBP. (A) The dose of a flat SOBP and its beam constituents. The higher energy beams contribute more to the total dose. (B) In a downslope target dose profile, the intensities of the lower energy beams are higher than in panel (A). (C) The LET_d distribution from the flat SOBP. (D) The LET_d distribution from the downslope field.