Figure 5.

Aged 9 and 13-month APP_swePS1_ΔE9 × IFNAR1^−/− brains exhibit unaltered Aβ burden compared to APP_swePS1_ΔE9 mice. Brain sections from 9 and 13-month old APP_swePS1_ΔE9 and APP_swePS1_ΔE9 × IFNAR1^−/− were stained with anti-Aβ antibodies for automated plaque analysis. Representative hippocampal and cortical sections for each age of APP_swePS1_ΔE9 and APP_swePS1_ΔE9 × IFNAR1^−/− are shown in (a). Measurements of (b) cortical plaque size, (c) cortical plaque burden and (d) plaques per mm² are shown. Measurements of hippocampal measures for each are shown in (e) to (g) respectively. Data is displayed as mean ± SEM, n = 3–6). Scale bar = 2 mm.