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. 2020 Feb 21;11:1005. doi: 10.1038/s41467-020-14735-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c Overlay of the LeuT_W8A structure in inward-facing occluded conformation (this study; light blue) with LeuT in the outward-facing occluded state (PDB-ID: 2A65¹⁰; light pink). a Close-up view of the intracellular vestibule region from the membranous side with transmembrane segments (TMs) 1, 5, and Y268 residue labelled. b Close-up view of the intracellular vestibule from the cytoplasmic side with TM1, 5 and internal gate residues (Y268, Q361, and D369) labelled and shown as colored sticks. c Close-up view of sodium and substrate binding sites with selected coordinating residues labelled and shown as colored sticks. For each structure, two sodium ions are shown as spheres and substrates as darker sticks in the corresponding colors. Residues are selected within a distance of 4 Å. d–f Overlay of the LeuT_W8A structure in inward-facing occluded conformation (this study; light blue) with LeuT structure in apo inward-facing open state (PDB-ID: 3TT1¹¹; light brown). Panel presentation is identical as in a–c.