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. 2020 Feb 21;10:3161. doi: 10.1038/s41598-020-59939-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Study design and selection of plasma miRNA candidates. (a) Study design to find novel plasma miRNA biomarkers for chemoresistance to 5-FU in GC. (b) Selection of plasma miRNA candidates from a comprehensive miRNA array-based approach. Using a miRNA array-based approach, we found increases in plasma miRNAs by comparing the plasma levels of each miRNA between GC patients with and without recurrences.