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. 2020 Feb 21;10:3161. doi: 10.1038/s41598-020-59939-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Large-scale analysis of the miR-1229-3p plasma level in GC patients with recurrences and without recurrences. (a) We observed that the plasma level of miR-1229-3p was significantly higher in GC patients with recurrences than in those without recurrences (P < 0.0001). A waterfall plot demonstrated a similar result (P < 0.0001). (b) Receiver-operating characteristic (ROC) curves and area under the ROC curve (AUC) values were used to assess the feasibility of using plasma miRNA levels as a diagnostic tool for detecting recurrences. We calculated the AUC value to be 0.807. The optimal relative expression cut-off point was indicated to be 25.8, with a sensitivity of 73.7% and a specificity of 80.5%. (c) A high level of plasma miR-1229-3p was significantly associated with poor prognosis.