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. 2020 Feb 21;11:1000. doi: 10.1038/s41467-020-14802-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a. Circos plot showing the 500 top-ranked lncRNA–pathway pairs across cancer types. The inner heat map shows the differential expression of lncRNAs across cancer types. Red and yellow colors represent upregulation; blue and green colors represent downregulation. b The overlap of immune–lncRNA pathways in independent datasets of the same cancer type. The top bar plots show the observed/expected values of the hypergeometric test. The bottom Venn plots show the number of overlapping lncRNA–pathway pairs. ***all P < 2.2E-16, two-sided hypergeometric tests. c The left heat map shows the proportion of differentially expressed lncRNAs of all lncRNAs and of immune-related lncRNAs. The right panel shows the odds ratios in each cancer type. All P < 0.01, two-sided Fisher’s exact tests. The error bars were 95% confidence levels of odds ratios. Source data are provided as a Source Data file.