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. 2020 Feb 21;11:1000. doi: 10.1038/s41467-020-14802-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The mutation burden for patients in different subtypes. n1 = 392, n2 = 253, and n3 = 343 biologically independent samples examined. P-values for one-sided Wilcoxon’s rank-sum tests. b The HRD score distribution for patients in different subtypes. n1 = 405, n2 = 253, and n3 = 352 biologically independent samples examined. P-values for one-sided Wilcoxon’s rank-sum tests. c Heat map showing 160 immune-related gene signature scores for patients across different subtypes. d The distribution of P-values obtained by ANOVA analysis. The pie plot shows the proportion of signatures with different P-values. e The cumulative distribution of immune, CYT, and MHC scores for patients of different cancer subtypes. f The proportion of patients that respond to chemotherapy in different subtypes. Two-sided Fisher’s exact test. g Diagram of the immune checkpoint pathway, comparing tumors in different subtypes. h Summary of features for patients of different subtypes. The center of the boxplots are median values, the bounds of the boxes are 25% and 75% quantiles. The minima are 25% quantile − 1.5*interquartile range (IQR) and the maxima are 75% quantile + 1.5*IQR. Source data are provided as a Source Data file.