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. 2020 Feb 21;10:3137. doi: 10.1038/s41598-020-60129-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LDIR upregulate the expression of several pro-angiogenic factors in Fli1:EGFP zebrafish in a VEGFR-dependent manner. Fli1:EGFP zebrafish larvae were exposed or not to 0.5 Gy at 3, 4 and 5 dpf and pre-treated or not with PTK/ZK, 30 minutes before each irradiation. The mRNA expression of flt1, kdr, angpt2a, tgfb2, fgf2, and cyr61 from whole cell suspension and endothelial sorter cells was quantified by qRT-PCR and normalized to elongation factor 1. (A) Data represent the relative mRNA levels of whole cell suspension and endothelial sorted cells from larvae exposed LDIR relative to the non-irradiated one (dashed line), in triplicate measurements. **P < 0.01; ***P < 0.001; ns, non-significant. (B) Data represent the fold change in mRNA expression of whole cell suspension and endothelial sorted cells of irradiated larvae exposed to PTK-ZK relative to non-irradiated and untreated ones, in triplicate measurements. Data are representative of six independent experiments.