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. 2020 Feb 21;10:3184. doi: 10.1038/s41598-020-60159-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term alterations on kynurenine pathway generated by Pb²⁺ treatment during lactation period of mice. (A) KAT II activity, (B) KYNA levels, (C) KMO activity and (D) 3-HK levels were evaluated in hippocampus, striatum, cortex and cerebellum of mice at 60 PND. Data are mean ± S.E.M. *P < 0.01 vs. each respective brain region control, T-test and Mann-Whitney test. N = 8 per group.