Table 2.
Rare CNV Burden Analysis in Cases and Controls.
| ASD cases (n = 128) | Controls (n = 363) | P value | ASD cases (n = 128) | Controls (n = 363) | P value | ||
|---|---|---|---|---|---|---|---|
| All CNVs | Deletions | ||||||
| N | 253 | 639 | N | 134 | 295 | ||
| RATE | 1.977 | 1.76 | 0.073793 | RATE | 1.047 | 0.8127 | 0.009399 |
| PROP | 0.8984 | 0.8154 | 0.019098 | PROP | 0.6641 | 0.5372 | 0.008099 |
| TOTKB | 296.1 | 352.6 | 0.823018 | TOTKB | 166.4 | 226.2 | 0.815718 |
| AVGKB | 143.5 | 156.3 | 0.679432 | AVGKB | 112.9 | 144 | 0.720728 |
| SFARI genes, all CNVs | SFARI genes, deletions | ||||||
| N | 33 | 57 | N | 23 | 36 | ||
| GRATE | 0.2578 | 0.157 | 0.039896 | GRATE | 0.1797 | 0.09917 | 0.042196 |
| GPROP | 0.1953 | 0.1295 | 0.050795 | GPROP | 0.1562 | 0.08264 | 0.015199 |
N: Number of events; RATE: Number of CNVs per person; PROP: Proportion of cases/controls to have at least one CNV; TOTKB: Total kb length spanned per person; AVGKB: Average segment size per person; GRATE: Number of SFARI genes spanned by CNVs per person; GPROP: Proportion of cases/controls to have CNVs spanning at least one SFARI gene.