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. 2019 Dec 27;8(1):A0078. doi: 10.5702/massspectrometry.A0078

Fig. 7. (A) Schematic illustrating the three-point “Pirkle Rule” required for chiral recognition. Chiral IMS separation utilizes stereochemically different noncovalent interactions between the enantiomers (1 and 2) and the chiral modifier (3), (B) Effect of chirality and flow rate of the modifier on the arrival times of the methionine enantiomers. The figure shows retardation in mobility of methionine enantiomers with increasing concentration of either (S)-(+)-2-butanol or (R)-(−)-2-butanol as the chiral modifiers in nitrogen drift gas. Better separation of enantiomers was observed with (S)-(+)-2-butanol as the chiral modifier (separation factor of 1.01) as compared to (R)-(−)-2-butanol (separation factor of 1.006). Reprinted with permission from P. Dwivedi, C. Wu, L. M. Matz, B. H. Clowers, W. F. Siems, H. H. Hill. Jr, Gas-phase chiral separations by ion mobility spectrometry, Anal. Chem. (2006) 78, 24, 8200–8206. Copyright © 2006 American Chemical Society.

Fig. 7. (A) Schematic illustrating the three-point “Pirkle Rule” required for chiral recognition. Chiral IMS separation utilizes stereochemically different noncovalent interactions between the enantiomers (1 and 2) and the chiral modifier (3), (B) Effect of chirality and flow rate of the modifier on the arrival times of the methionine enantiomers. The figure shows retardation in mobility of methionine enantiomers with increasing concentration of either (S)-(+)-2-butanol or (R)-(−)-2-butanol as the chiral modifiers in nitrogen drift gas. Better separation of enantiomers was observed with (S)-(+)-2-butanol as the chiral modifier (separation factor of 1.01) as compared to (R)-(−)-2-butanol (separation factor of 1.006). Reprinted with permission from P. Dwivedi, C. Wu, L. M. Matz, B. H. Clowers, W. F. Siems, H. H. Hill. Jr, Gas-phase chiral separations by ion mobility spectrometry, Anal. Chem. (2006) 78, 24, 8200–8206. Copyright © 2006 American Chemical Society.