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. 2019 Dec 27;8(1):A0078. doi: 10.5702/massspectrometry.A0078

Fig. 9. Protein DESI-MS spectra of normal and high-grade serous ovarian cancer ovarian tumor with optimized FAIMS parameters. Mass spectra are averages of 10 scans. Different charge states of the same protein species are denoted by same-colored labels. (b) Zoomed in mass spectra of normal and high-grade serous ovarian cancer samples, highlighting the observance of m/z 1442.339, identified as S100A6, within the cancer tissue. (c) DESI-MS ion images obtained from normal, pure cancer, and mixed normal/cancer ovarian tissue sections. Ion images are on the same scale. H&E stained images are of a serial ovarian tissue sections as protein conditions are not histologically compatible. Reprinted from K. Y. Garza, C. L. Feider, D. R. Klein, J. A. Rosenberg, J. S. Brodbelt, L. S. Eberlin, Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections, Anal. Chem. (2018), 90, 13, 7785–7789 with permission. Copyright © 2018 American Chemical Society.

Fig. 9. Protein DESI-MS spectra of normal and high-grade serous ovarian cancer ovarian tumor with optimized FAIMS parameters. Mass spectra are averages of 10 scans. Different charge states of the same protein species are denoted by same-colored labels. (b) Zoomed in mass spectra of normal and high-grade serous ovarian cancer samples, highlighting the observance of m/z 1442.339, identified as S100A6, within the cancer tissue. (c) DESI-MS ion images obtained from normal, pure cancer, and mixed normal/cancer ovarian tissue sections. Ion images are on the same scale. H&E stained images are of a serial ovarian tissue sections as protein conditions are not histologically compatible. Reprinted from K. Y. Garza, C. L. Feider, D. R. Klein, J. A. Rosenberg, J. S. Brodbelt, L. S. Eberlin, Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections, Anal. Chem. (2018), 90, 13, 7785–7789 with permission. Copyright © 2018 American Chemical Society.