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A schematic picture of PNA-LNA mediated LAMP. When the target is wild-type sequence, the 450 clamping PNA probe forms a stable duplex with the dumbbell structure, and interferes with the 451 annealing and elongation of the LNA primer. When the target DNA has mutated sequence, the 452 clamping PNA probe does not anneal with the DNA because of the single-base mismatch, and the 453 elongation reaction proceeds.
