Table 1.
Case | Age at diagnosis (years) | SOT | Time from SOT to PTLD diagnosis (years) | PTLD location | Immunosuppressive regimen | Histologic subtype | EBV status | Treatments | SOT failure | Patient status |
---|---|---|---|---|---|---|---|---|---|---|
1 | 66 | Deceased donor kidney | 12 | Duodenum | Tacrolimus, mycophenolate mofetil | Burkitt | Negative | ROI, R-EPOCH | No | Alive |
2 | 53 | Live donor kidney | 7 | Stomach, retroperitoneal (RP) lymph nodes (LNs), bone marrow | Tacrolimus, prednisone | RP LN: polymorphic, bone marrow: Hodgkin | Positive | ROI, rituximab, R-GEMOX, AVD | Yes | Alive |
3 | 52 | Deceased donor kidney, live donor kidney | 30, 16 | CNS, oropharynx, lung | Cyclosporine, mycophenolate mofetil, prednisone | Oropharynx: polymorphic, CNS and lung: Hodgkin | Positive | ROI, rituximab, high-dose MTX, brentuximab, high-dose cytarabine | No | Deceased |
4 | 73 | Kidney | 11 | CNS | Mycophenolate mofetil, prednisone | Diffuse large B cell | Positive | Unknown | Unknown | Unknown |
5 | 74 | Live donor kidney | 10 | CNS | Tacrolimus, mycophenolate mofetil, prednisone | Diffuse large B cell | Positive | None | Unknown | Unknown |
SOT: solid organ transplantation; PTLD: posttransplant lymphoproliferative disorder; CNS: central nervous system; ROI: reduction of immunosuppression; R-EPOCH: rituximab, etoposide, prednisone, vincristine, cyclophosphamide, adriamycin; R-GEMOX: rituximab, gemcitabine, oxaliplatin; AVD: adriamycin, vinblastine, dacarbazine.