Table 1.
Demographics and baseline characteristics of PTP subjects
| All subjects | ceBMI <0 kg/m2 | ceBMI ≥0 kg/m2 | ||
|---|---|---|---|---|
| Characteristic | N = 706 | N = 517 | N = 189 | P |
| Age at single Ab+ (years), median (range) | 9.8 (1.2–17.9) | 9.9 (1.2–17.9) | 9.4 (1.6–17.6) | 0.97 |
| Sex | 0.78 | |||
| Male | 347 (49.2) | 252 (48.7) | 95 (50.3) | |
| Female | 359 (50.8) | 265 (51.3) | 94 (49.7) | |
| Ab type | 0.85 | |||
| GADA+ | 460 (65.1) | 340 (65.8) | 120 (63.5) | |
| IA-2A+ | 33 (4.7) | 24 (4.6) | 9 (4.8) | |
| IAA+ | 213 (30.2) | 153 (29.6) | 60 (31.7) | |
| Race | 0.67 | |||
| White | 577 (81.7) | 425 (82.2) | 152 (80.4) | |
| Nonwhite/unknown | 129 (18.3) | 92 (17.8) | 37 (19.6) | |
| Ethnicity | 0.0001 | |||
| Hispanic/Latino | 118 (16.7) | 69 (13.3) | 49 (25.9) | |
| Non-Hispanic/Latino | 564 (79.9) | 430 (83.2) | 134 (70.9) | |
| Unknown/missing | 24 (3.4) | 18 (3.5) | 6 (3.2) | |
| HLA haplotype | ||||
| DR3 and/or DR4-DQ8 | 0.92 | |||
| No | 205 (29.1) | 151 (29.3) | 54 (28.6) | |
| Yes | 499 (70.9) | 364 (70.7) | 135 (71.4) | |
| DR3-DQ2 | 0.99 | |||
| No | 408 (58.0) | 298 (57.9) | 110 (58.2) | |
| Yes | 296 (42.0) | 217 (42.1) | 79 (41.8) | |
| DR4-DQ8 | 0.80 | |||
| No | 432 (61.4) | 318 (61.7) | 114 (60.3) | |
| Yes | 272 (38.6) | 197 (38.3) | 75 (39.7) | |
| Missing | 2 | 2 | 0 | |
| Baseline BMI percentile | <0.0001 | |||
| Underweight (<5%) | 26 (3.7) | 24 (4.6) | 2 (1.0) | |
| Normal (≥5%, <85%) | 505 (71.5) | 468 (90.5) | 37 (19.6) | |
| Overweight (≥85%, <95%) | 84 (11.9) | 20 (3.9) | 64 (33.9 | |
| Obese (≥95%) | 91 (12.9) | 5 (1.0) | 86 (45.5) | |
| Baseline ceBMI (kg/m2) | <0.0001 | |||
| Median | −1.92 | −2.6 | 2.54 | |
| Range | −9.2 to 15.7 | −9.2 to 15.7 | −5.7 to 14.2 | |
| Baseline BMI category | <0.0001 | |||
| Normal (<0 kg/m2) | 531 (75.2) | 492 (95.2) | 39 (20.6) | |
| Overweight (≥0 kg/m2) | 175 (24.8) | 25 (4.8) | 150 (79.4) | <0.0001 |
Data are n (%) unless otherwise indicated. Ab, autoantibody; GADA, GAD autoantibody; IA-2A, IA-2 autoantibody; IAA, insulin autoantibody.