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. 2020 Feb 22;11:8. doi: 10.1186/s13293-020-00285-9

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Differences between male and female rats in the Akt/GSK3/β-catenin signaling pathway. Modulation of Akt. Phosphorylation of Akt at Ser473 (a) and Thr308 (b). At basal level, Akt was more active (more phosphorylated) in male than in female (p < 0.0001) for both sites. SKF 83959 increased the phosphorylation of Akt on both sites, pThr308-Akt (a) and pSer473-Akt (b), in female rats. Pre-treatment with TAT-D1 peptide blocked the SKF 83959 effects on pSer473 but had no notable effect on pThr308 site in female rats. No effect of treatment was observed in the NAc of male rats. N = 6 rats/group. Data are means ± SEM