Table 2.
Semiquantitative, volumetric and dynamic contrast-enhanced MRI assessment at 7 T MRI
| Parameter | Patient | Intra-reader Agreement d |
Inter-reader Agreement d |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |||
| Semiquantitative scoring | ||||||||||||
| Hoffa-Synovitis-score (IW-FS) a | 1 | 1 | 1 | 1 | 2 | 3 | 3 | 1 | 0 | 1 |
0.76 [0.45 to 1.05] |
0.21 [0.18 to 0.61] |
| Effusion-Synovitis-score (IW-FS) a | 3 | 2 | 2 | 3 | 3 | 2 | 2 | 3 | 2 | 2 |
0.64 [0.20 to 1.08] |
1.00 [1.00 to 1.00] |
| 11-site score (summed; T1-FS CE) b | 11 | 12 | 18 | 8 | 18 | 6 | 12 | 6 | 9 | 13 |
0.93 [0.77 to 0.98] |
0.93 [0.75 to 0.98] |
| Synovitis severity b | moderate | moderate | severe | mild | severe | mild | moderate | mild | moderate | moderate | n/a | n/a |
| Peripatellar T1-FS CE(2 sites) c | 3 | 4 | 6 | 3 | 6 | 2 | 3 | 1 | 2 | 3 |
0.89 [0.74 to 1.02] |
0.87 [0.75 to 1.02] |
| Peripatellar FLAIR-FS(2 sites) c | 2 | 4 | 5 | 2 | 4 | 1 | 2 | 0 | 1 | 3 |
0.77 [0.59 to 0.94] |
0.68 [0.49 to 0.88] |
| Volume (cmc) | ||||||||||||
| T1-FS CE | 14.74 | 13.61 | 15.24 | 12.98 | 9.27 | 12.30 | 6.22 | 6.46 | 9.75 | 9.83 |
0.93 [0.69 to 0.98] |
0.98 [0.93 to 0.99] |
| FLAIR-FS | 11.59 | 10.47 | 14.18 | 10.01 | 8.78 | 9.40 | 5.37 | 5.70 | 8.31 | 9.01 |
0.91 [0.60 to 0.98] |
0.88 [0.59 to 0.97] |
| 3D-DCE | ||||||||||||
| Wash-in | 1.12 ± 0.81 | 0.67 ± 0.41 | 2.23 ± 1.79 | 1.06 ± 1.02 | 1.84 ± 2.66 | 2.51 ± 2.98 | −0.25 ± 1.59 | 1.38 ± 1.55 | 1.72 ± 1.21 | 2.41 ± 2.82 |
0.97 [0.99 to 0.99] |
0.87 [0.78 to 0.92] |
| Wash-out | 0.17 ± 0.24 | 00.42 ± 0.36 | 0.11 ± 0.37 | 0.19 ± 0.38 | − 0.02 ± 0.50 | 0.15 ± 0.71 | 0.68 ± 0.39 | 0.13 ± 0.36 | 0.11 ± 0.36 | − 0.01 ± 0.59 |
0.95 [0.89 to 0.97] |
0.91 [0.84 to 0.94] |
| TTP | 1.04 ± 0.44 | 0.93 ± 0.68 | 0.86 ± 0.58 | 0.96 ± 0.30 | 0.93 ± 0.38 | 1.03 ± 0.29 | 1.29 ± 0.51 | 0.86 ± 0.34 | 0.70 ± 0.22 | 0.63 ± 0.12 |
0.82 [0.71 to 0.89] |
0.79 [0.67 to 0.88] |
| PE | 0.93 ± 1.49 | 1.68 ± 1.12 | 2.19 ± 1.35 | 2.56 ± 2.94 | 1.78 ± 1.89 | 5.32 ± 6.86 | 3.36 ± 3.68 | 2.15 ± 2.33 | 1.93 ± 1.03 | 2.55 ± 2.49 |
0.99 [0.98 to 0.99] |
0.86 [0.78 to 0.92] |
| iAUC | 0.67 ± 0.53 | 0.69 ± 0.55 | 1.16 ± 0.81 | 1.09 ± 1.55 | 0.82 ± 1.07 | 1.91 ± 2.58 | 0.88 ± 1.02 | 0.85 ± 1.10 | 1.00 ± 0.65 | 1.69 ± 2.20 |
0.99 [0.99 to 0.99] |
0.88 [0.80 to 0.93] |
a Hoffa- and effusion synovitis was scored semiquantitatively from 0 to 3 on the sagittal IW-FS sequence
b Summed 11-site whole-joint semiquantitative score (from 0 to 3): the medial and lateral peripatellar recess, suprapatellar, infrapatellar, intercondylar, medial and lateral perimeniscal, and adjacent to the anterior and posterior cruciate ligaments. If knees presented with Baker’s cysts or loose bodies, these two sites were scored in addition. For assessment of whole-knee synovitis the scores of the 11 sites were summed and categorized: 0–5 normal or equivocal synovitis; 6–9 mild synovitis; 10–13 moderate synovitis and ≥ 14 severe synovitis adapted from reference 16
c Scored at the medial and lateral peripatellar recess from 0 to 3 at level 2 (see Fig. 1a) - adapted from reference 16
d Weighted Kappa statistics were used for ordinal scores and intraclass correlation coefficients (ICC) were used for continuous variables
Data are means ± standard deviations, unless indicated otherwise. Numbers in parentheses are 95% confidence intervals
Abbreviations: T1-FS CE T1-weighted fat suppressed contrast-enhanced sequence, FLAIR-FS Fluid attenuated inversion recovery fat suppressed sequence, 3D-DCE Three dimensional dynamic contrast enhanced sequence, S0 Pre-contrast signal intensity, Smax Maximum signal intensity, a.u Arbitrary unit, Wash in: average slope during initial (first 30 s) enhancement (a.u/min); Wash out: average slope in the washout (last 30 s) phase (a.u/min); TTP Time to peak (s), PE Peak enhancement ratio (Smax – S0)/S0; iAUC Initial area under the curve (first 60s, a.u.min)