Table 3.
Selected candidate mRNA-microRNA pairs
| microRNA | mRNA | Correlation | Log2 Fold Change B1 vs B2 | TNBC Pro-Survival Direction | Predicted Binding | ||||
|---|---|---|---|---|---|---|---|---|---|
| PCC | adj. p-value | miRNA | mRNA | miRNA | mRNA | Orientation | mRNA | ||
| hsa-mir-17 | IL1R1 | −0.56 | 1.17e-12 | 1.04 | −1.09 | Down | UP | 3p | IL1R1 |
| hsa-mir-17 | INPP4B | −0.55 | 4.21e-12 | 1.04 | −1.31 | Down | UP | 3p | INPP4B |
| hsa-mir-18a | APH1B | −0.52 | 1.46e-10 | 0.98 | −0.55 | Down | UP | 3p | (APH1A) |
| hsa-mir-18a | CPEB4 | −0.50 | 6.02e-10 | 0.98 | −0.83 | Down | UP | 3p | (CPEB1/3) |
| hsa-mir-18a | FAM214A | −0.52 | 1.00e-10 | 0.98 | −0.54 | Down | UP | 3p | (FAM214B) |
| hsa-mir-18a | INPP4B | −0.52 | 1.62e-10 | 0.98 | −1.31 | Down | UP | 3p | INPP4B |
| hsa-mir-18a | KCNMA1 | −0.50 | 6.79e-10 | 0.98 | −1.04 | Down | UP | 5p | KCNMA1 |
| hsa-mir-18a | MAN2B2 | −0.54 | 1.17e-11 | 0.98 | −0.52 | Down | UP | 3p | (MAN2B1) |
| hsa-mir-18a | THSD4 | −0.52 | 7.80e-11 | 0.98 | −0.92 | Down | UP | 3p | THSD4 |
| hsa-mir-19a | IL1R1 | −0.52 | 9.24e-11 | 0.87 | −1.09 | Down | UP | 3p + 5p | IL1R1 |
mRNA-microRNA pairs computed by the integrative analysis combining correlation, differential expression, survival and target analysis. PCC Pearson correlation coefficient. Target mRNAs in parenthesis are paralogs of the investigated mRNAs