Table 1.
Clinical characteristics on admission to the weaning center
| All patients (n = 263) | Weaning success (n = 126) | Weaning failure (n = 137) | P valuea | |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Age (years) | 70.9 (± 11.0) | 71.0 (± 11.4) | 70.7 (± 10.6) | 0.404b |
| Gender (male) | 161 (61.2) | 87 (69.0) | 74 (54.0) | 0.012c |
| Body mass index (kg/m2) | 26.4 (± 6.2) | 25.1 (± 4.4) | 27.7 (± 7.3) | < 0.001b |
| Obesity (BMI ≥ 30 kg/m2) | 54 (20.5) | 16 (12.7) | 38 (27.7) | 0.003c |
| Smoking history | 120 (45.6) | 50 (39.7) | 70 (51.1) | 0.063c |
| APACHE-II (points) | 17.7 ( 5.1) | 17.6 (± 4.6) | 17.9 (± 5.5) | 0.350b |
| Albumin (g/dL) | 2.0 (± 0.5) | 2.0 (± 0.5) | 2.0 (± 0.5) | 0.190b |
| Ventilator days on admission (days) | 26.7 (± 21.6) | 24.2 (± 17.2) | 29.0 (± 24.8) | 0.034b |
| Time from intubation to tracheostomy (days) | 10.6 (± 6.7) | 10.7 (± 6.5) | 10.4 (± 6.9) | 0.395b |
| ECLA | 11 (4.2) | 8 (6.3) | 3 (2.2) | 0.092c |
| Cause of acute respiratory failure | ||||
| Pneumonia | 77 (29.3) | 42 (33.3) | 35 (25.5) | 0.166c |
| Surgery | 74 (28.1) | 38 (30.2) | 36 (26.3) | 0.484c |
| Sepsis (including septic shock) | 29 (11.0) | 14 (11.1) | 15 (10.9) | 0.967c |
| Acute exacerbation of COPD | 26 (9.9) | 2 (1.6) | 24 (17.5) | < 0.001c |
| Cardiopulmonary resuscitation | 22 (8.4) | 11 (8.7) | 11 (8.0) | 0.837c |
| Cardiac failure | 8 (3.0) | 4 (3.2) | 4 (2.9) | 0.904c |
| Trauma | 5 (1.9) | 3 (2.4) | 2 (1.7) | 0.673d |
| Other | 22 (8.4) | 12 (9.5) | 10 (7.3) | 0.515c |
| Comorbidities | ||||
| Charlson comorbidity index (points) | 6.6 (± 2.4) | 6.5 (± 2.4) | 6.7 (± 2.5) | 0.268b |
| Coronary artery disease | 89 (33.8) | 43 (34.1) | 46 (33.6) | 0.925c |
| COPD | 65 (24.7) | 15 (11.9) | 50 (36.5) | < 0.001c |
| Diabetes mellitus | 82 (31.2) | 39 (31.0) | 43 (31.4) | 0.939c |
| Chronic heart failure | 53 (20.2) | 22 (17.5) | 31 (22.6) | 0.297c |
| Renal insufficiency (GFR < 60 mL/min) | 74 (28.1) | 30 (23.8) | 44 (32.1) | 0.134c |
| Hemodialysis on admission | 34 (12.9) | 12 (9.5) | 22 (16.1) | 0.115c |
| Malignancy | 37 (14.1) | 22 (17.5) | 15 (10.9) | 0.129c |
| Hepatopathy | 13 (4.9) | 8 (6.3) | 5 (3.6) | 0.313c |
| Interstitial lung disease | 12 (4.6) | 7 (5.6) | 5 (3.6) | 0.459c |
| Neuromuscular disease | 12 (4.6) | 7 (5.6) | 5 (3.6) | 0.459c |
Continuous variables are presented as mean values (± standard deviation); categorical variables are presented as number (%)
aP value for differences between patients with weaning success and weaning failure
bStudent’s t test
cChi-squared test
dFisher’s exact test
BMI body mass index, APACHE-II Acute Physiology and Chronic Health Evaluation II score, ECLA extracorporeal lung assistance (in acute respiratory failure), COPD chronic obstructive pulmonary disease, GFR glomerular filtration rate