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. 2020 Feb 21;18:94. doi: 10.1186/s12967-020-02271-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Immunohistochemical stainings of PPARγ, Cox-1 and Cox-2 expression in breast carcinoma of 3 patients and a box-plot of nuclear PPARγ and Grading. PPARγ (a, d, g), Cox-1 (b, e, h) and Cox-2 (c, f, i) stainings are illustrated for patients with different grading (Grade 1 in a–c, 2 in d–f and 3 in g–i), with examples of null, average or high expressions. Nucleo:cytoplasmic IRS ratios are indicated in each photomicrograph (×25 magnification) and scale bar equals 100 μm. An enlargement of g (high cytoplasmic and null nuclear PPARγ staining) is presented (j) and scale bar equals 50 μm. Correlation between nuclear PPARγ and grading was presented as box plot (k). The boxes represent the range between the 25th and 75th percentiles with a horizontal line at the median. The bars on top and below depict the 5th and 95th percentiles. Values more than 1.5 box lengths from the 75th percentile are indicated by circles (none) and values more than 3.0 box lengths from the 75th percentile are indicated by asterisks. The numbers on asterisks represent the case number. Statistical significance is shown as p-value from Kruskal–Wallis test (**p < 0.01)