Table 2.
Distribution of expression of PPARγ, Cox-1 and Cox-2
| PPARγ | Cox-1 | Cox-2 | |||
|---|---|---|---|---|---|
| Total | Nuclear | Cytoplasmic | |||
| n | 262 | 262 | 262 | 297 | 285 |
| Mean IRS ± SE | 4.37 ± 0.17 | 0.27 ± 0.04 | 4.09 ± 0.17 | 0.34 ± 0.04 | 5.19 ± 0.19 |
| IRS range | 12 | 4 | 12 | 4 | 12 |
| IRS cut-off | 3.5 | 0.5 | 3.5 | 0.5 | 1.5 |
| Number of samples with negative/low expression | 111 (42.4%) | 213 (81.3%) | 124 (47.3%) | 224 (75.4%) | 36 (12.6%) |
| Number of samples with positive/high expression | 151 (57.6%) | 49 (18.7%) | 138 (52.7%) | 73 (24.6%) | 249 (87.4%) |
IRS cut-offs were defined by performing a ROC-curve analysis for DFS. The cut-off of 0.5 for nuclear PPARγ and for Cox-1 stainings, related to the low expression level of both markers in our cohort, define negative and positive expressions, instead of low and high expressions sub-groups respectively