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. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Mol Pharm. 2019 Jun 27;16(8):3414–3429. doi: 10.1021/acs.molpharmaceut.9b00208

Figure 14.

Figure 14.

Effect of liposomal fasudil on the pulmonary hemodynamics in Sugen/hypoxia PAH rats after administration of (A) fasudil in no-CAR-liposomes, (B) CAR pretreatment followed by fasudil in no-CAR-liposomes and (C) fasudil in CAR-liposomes. (D) Targeting indices of fasudil after IT administration in various forms. The dose of fasudil was 3 mg/kg (rat body weight) or liposomes containing equivalent amount of fasudil and the dose of CAR was 0.5 mg/kg (data represent mean ± SD, n = 3; *p < 0.05, §p < 0.005, Ƶp < 0.001).