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. Author manuscript; available in PMC: 2020 Feb 22.
Published in final edited form as: Mol Pharm. 2019 Jun 27;16(8):3414–3429. doi: 10.1021/acs.molpharmaceut.9b00208

Table 1.

Physical Characteristics and Drug Contents of the Liposomes Containing Fasudila

sonication drug
formulations rotation speed rotation time (h) solubilization of dry films and then sonication direct sonication without solubilization of the dry film solution powder zeta potential (mV) size (nm) PDI encapsulation (%)
F1 50 1 × × −30.4 ± 11.3 212.1 ± 1.3 0.05 ± 0.01 46.5 ± 2.5
F2 150 1 × × −28.35 ± 5.5 205.2 ± 0.8 0.07 ± 0.06 77 ± 2.4
F3 250 1 × × −26.9 ± 14.8 209.7 ± 2.6 0.08 ± 0.02 31 ± 5.3
F4 150 12 × × 206.2 ± 2.8 0.03 ± 0.01 62.1 ± 8
F5 150 1 × × 203.6 ± 1.2 0.06 ± 0.01 95.5 ± 4.5
F6 150 1 × × 179.6 ± 8.1 0.07 ± 0.02 95.5 ± 4.5
a

Data represent mean ± SD, n = 3.