Sarsfield 1979.
Methods | A double blind cross over study in the UK. | |
Participants | 27 children (21 boys, 6 girls) 7‐16 years. Mean:12.3 years with perennial rhinitis. | |
Interventions | Nasal spray of flunisolide as an aqueous propylene glycol solution (0.025% w/v) in a glass bottle fitted with a mechanical pump delivering 0.1 ml per actuation, or placebo. Intervention or placebo for 4 weeks and crossed over. One spray in each nostril three times per day at 8‐hourly intervals. A total daily dose of 150 micrograms. | |
Outcomes | Weekly diary cards by participants or parents, severity of : sneezing, stuffy nose, runny nose and nose blowing rated: 0 = none, 1 = mild, 2 = moderate, 3 = severe. Clinical assessments at enrollment and the end of each treatment period. Severity of allergic symptoms (sneezing, stuffy nose, runny nose, nose blowing, post nasal drip, epistaxis, and throat itch) during the previous month was recorded by direct questioning and scored 0‐3. | |
Notes | No indication of whether concomitant or rescue medications were prohibited during the trial, and no wash out period was specified. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |