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. 2020 Feb 18;15:1149–1160. doi: 10.2147/IJN.S236922

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© 2020 Xu et al.

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Drug treatment regulated the activity of neurons in vitro. (A) The images of PC12 cells injured by various concentrations of Aβ_25–35 solution. (B) The treatment of PC12 cells with Aβ_25–35 (10, 20, and 40 μM) alone for 24 hrs was represented by the MTT assay. (C) The inhibiting effects of RIN or T80-NPS-RIN (12.5 and 25 μM) were investigated through pretreatment for 4 hrs. (D, E) The effect of RIN, NPS-RIN and T80-NPS-RIN in Aβ_25–35-induced apoptosis PC12 cells were double-stained with Annexin V PE/7-AAD and analyzed by flow cytometry. Values were the mean ± SD (n = 3). **P < 0.01, and ***P < 0.001 compared to the control groups. ^#P < 0.05 and ^##P < 0.01 vs the Aβ group. ^###P < 0.001, T80-NPS-RIN compared with Aβ solution therapy.