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. 2020 Feb 18;12:1229–1240. doi: 10.2147/CMAR.S231872

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© 2020 Liu et al.

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circPVT1 affects proliferation, migration and invasion via regulating EMT in OS cells. (A) After transfected with si-NC, si-circPVT1-1, si-circPVT1-2 and si-circPVT1-3, respectively, MG63 and U2OS cells were subjected for circPVT1 detection by qRT-PCR. (B) CCK-8 and (C) colony formation assays were performed in si-circPVT1 transfected MG63 and U2OS cells to examine the effects of circPVT1 knockdown on OS cell proliferation viability. After transfected with si-circPVT1, the (D) migratory and (E) invasive capacities of MG63 and U2OS cells were evaluated by transwell assay. (F) Western blot detection of E-cadherin, N-cadherin, Vimentin, and Snail in si-circPVT1 transfected MG63 and U2OS cells. The data were means ± SD of three independent assays, *P < 0.05; **P < 0.01.