FIG 11.

Inflammatory but not patrolling monocytes contribute to S. suis-induced central nervous system (CNS) inflammation. Brain levels of IL-1β (A), IL-6 (B), CCL2 (C), CCL3 (D), CXCL1 (E), and CXCL2 (F) in wild-type, CCR2^−/−, and Nr4a1^−/− mice following intracisternal mock infection (THB) or 6 h following infection with 10⁵ CFU of S. suis or upon presentation of clinical CNS disease. The data represent the mean ± SEM (n = 5). * (P < 0.05) indicates a significant difference in mediator levels between wild-type and CCR2^−/− mice as determined using the unpaired t test.