FIG 12.
The presence of neutrophils modulates S. suis-induced central nervous system (CNS) inflammation. Brain levels of IL-1β (A), IL-6 (B), CCL2 (C), CCL3 (D), CXCL1 (E), and CXCL2 (F) in wild-type mice pretreated with either isotype control or anti-Ly6G neutralizing antibody mice following intracisternal mock infection or 6 h following infection with 105 CFU of S. suis or upon presentation of clinical CNS disease. The data represent the mean ± SEM (n = 5). * (P < 0.05) indicates a significant difference in mediator levels between isotype control- and anti-Ly6G-treated mice as determined using the unpaired t test.