FIG 3.

Inflammatory but not patrolling monocytes participate in blood bacterial burden control following S. suis infection. Blood bacterial burden of wild-type, CCR2^−/−, and Nr4a1^−/− mice 6 h (A), 12 h (B), 24 h (C), and 48 h (D) following infection with S. suis by intraperitoneal inoculation. The data represent the geometric mean (n = 10). A blood bacterial burden of 2 × 10⁹ CFU/ml, corresponding to the average burden upon euthanasia, was attributed to euthanized mice. * (P < 0.05) indicates a significant difference between the blood bacterial burden of wild-type and CCR2^−/− mice as determined using the Mann-Whitney rank sum test.