FIG 8.

S. suis induces the infiltration of neutrophils, and to a lesser extent of inflammatory monocytes, into the central nervous system (CNS) following infection. Infiltrating CD45^hiCD11b^hiLy6G^hi neutrophils and CD45^hiCD11b^hiLy6G^lo monocytes in the CNS of mock-infected and S. suis-infected mice (upon presentation of clinical CNS disease) were analyzed using flow cytometry (A). Inflammatory (Ly6C^hi) and patrolling (Ly6C^lo) monocyte subpopulations (B) were determined by gating on the CD45^hiCD11b^hiLy6G^lo monocytes in panel A. The data represent the mean ± SEM (n = 3). * (P < 0.05) indicates a significant difference between mock-infected and S. suis-infected mice as determined using the Mann-Whitney rank sum test.