FIG 9.

Monocytes and neutrophils are not required for the development of clinical central nervous system (CNS) disease following S. suis infection. Survival of wild-type (black), CCR2^−/− (green), and Nr4a1^−/− (blue) mice (A), wild-type mice pretreated with either isotype control (black) or anti-Ly6G neutralizing antibody (red) (B), and CCR2^−/− mice pretreated with either isotype control (black) or anti-Ly6G neutralizing antibody (purple) (C) following intracisternal infection with 10⁵ CFU of S. suis. The data represent the survival curves of mice euthanized upon presentation of clinical signs of CNS disease (n = 10). Statistical differences were analyzed using the log-rank (Mantel-Cox) test.