FIG 2.

Dual role of miR-146a in the survival of mycobacteria. (A) Upon Mycobacterium bovis (BCG) infection in macrophages differentiated from human THP-1 cells, miR-146a increases its expression and downregulates transcription factors to suppress the inflammatory response leading to a reduction in mycobacterial survival. (B and C) After BCG infection in murine macrophages, miR-146a increases its expression and downregulates transcription factors and cytokines to suppress the inflammatory response leading to an increase in mycobacterial survival.