TABLE 1.

Differential miRNA expression profiles in different stages of tuberculosis

Samplea	No. of upregulated miRNAs	No. of downregulated miRNAs	No. of validated miRNAs	Participantsa	Reference
PBMC	28	2	1	PTB vs control	Liu et al., 2011 (78)
PBMC	9	1		LTBI vs ATB	Wu et al., 2014 (62)
		1		ATB vs control
	16	6		LTBI vs control
PBMC	15	14	8	ATB vs controlb	Zhou et al., 2016 (86)
CD4+ T cells	82	53	6	ATB vs control	Fu et al., 2014 (117)
	33	46		LTBI vs control
	62	62		LTBI vs ATB
Serum	59	33	3	ATB vs control	Fu et al., 2011 (57)
Serum	90	7	7	PTB vs control	Qi et al., 2012 (59)
Serum	44	47	6	PTB vs control	Zhang et al., 2013 (63)
Serum	62	33	2	ATB vs LTBI	Zhang et al., 2014 (60)
	82	22		ATB vs BCG+
	37	65		ATB vs BCG−
	24	6		ATB vs three groups
Serum	10	25		ATB vs control	Xu et al., 2015 (58)
Differentiated macrophages derived from PBMC	6	3	11	ATB vs control	Zheng et al., 2015 (53)
	8	1		LTBI vs control
	4			LTBI vs ATB
THP-1 cells	1	13	14	Beijing/W vs non-Beijing/W M. tuberculosis strains
Sputum	43	52	3	ATB vs control	Yi et al., 2012 (61)

^aATB, active tuberculosis; PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; PBMC, peripheral blood mononuclear cells.

^bSamples obtained from children (2 to 14 years old).