TABLE 4.
miRNAs involved in different disease stages validateda in different samples and studies
| Sample | Validated miRNA | Regulation | Individuals | Reference |
|---|---|---|---|---|
| PBMCs | hsa-miR-144* | Upregulated | PTB vs control | Liu et al., 2011 (78) |
| hsa-miR‑29b | Upregulated | Zhou et al., 2016 (86)b | ||
| hsa-miR‑1 | Downregulated | |||
| hsa-miR‑150 | Downregulated | |||
| hsa-miR‑155 | Downregulated | |||
| hsa-miR‑31 | Downregulated | |||
| hsa-miR‑146a | Downregulated | |||
| hsa-miR‑10a | Downregulated | |||
| hsa-miR‑125b | Downregulated | |||
| Serum | hsa-miR-93* | Upregulated | PTB vs control | Fu et al., 2011 (57) |
| hsa-miR-29a | Upregulated | |||
| hsa-miR-3125 | Downregulated | |||
| hsa-miR-361-5p | Upregulated | Qi et al., 2012 (59) | ||
| hsa-miR-889 | Upregulated | |||
| hsa-miR-576-3p | Upregulated | |||
| hsa-miR-210 | Upregulated | |||
| hsa-miR-26a | Upregulated | |||
| hsa-miR-432 | Upregulated | |||
| hsa-miR-134 | Upregulated | |||
| hsa-miR-378 | Upregulated | Zhang et al., 2013 (63) | ||
| hsa-miR-483-5p | Upregulated | |||
| hsa-miR-22 | Upregulated | |||
| hsa-miR-29c | Upregulated | |||
| hsa-miR-320b | Downregulated | |||
| hsa-miR-101 | Downregulated | |||
| hsa-miR-196b | Upregulated | ATB vs control | Zhang et al., 2014 (60) | |
| hsa-miR-376c | Upregulated | ATB vs LTBI/BCG− | ||
| hsa-miR-16 | Upregulated | PTB vs control and TB treated | Wagh et al., 2017 (56) | |
| hsa-miR-155 | Downregulated | |||
| hsa-miR-148b-3p | Upregulated | Control vs ATB; ATB vs partially treated TB; ATB vs cured TB | Wang et al., 2018 (55) | |
| hsa-miR-21-5p | Upregulated | |||
| hsa-miR-92a-3p | Upregulated | Control vs ATB; ATB vs cured TB | ||
| Has-miR-125a-5p | Upregulated | Partially treated TB vs untreated; partially treated TB vs cured TB | ||
| hsa-miR-144 | Upregulated | ATB vs control | Lv et al., 2016 (74) | |
| Sputum | hsa-miR-29a | Upregulated | PTB vs control | Fu et al., 2011 (57) |
| hsa-miR-19b-2* | Downregulated | Yi et al., 2012 (61) | ||
| hsa-miR-3179 | Upregulated | |||
| hsa-miR-147 | Upregulated | |||
| CD4+ cells | miR-451a | Upregulated | ATB vs control | Fu et al., 2014 (117) |
| miR-340-5p | Upregulated | |||
| miR-136-5p | Upregulated | |||
| miR-4292 | Downregulated | |||
| miR-29b | Upregulated | |||
| THP-1 cells | hsa-miR-16 | Upregulated | ATB vs control | Zheng et al., 2015 (53) |
| hsa-miR-137 | Upregulated | |||
| hsa-miR-140-3p | Upregulated | |||
| hsa-miR-193a-3p | Upregulated | |||
| hsa-miR-501-5p | Upregulated | |||
| hsa-miR-598 | Upregulated | |||
| hsa-miR-95 | Downregulated |
a
Expression of miRNAs was confirmed by real-time PCR (qPCR) after sequencing.
b
Samples obtained from children (2 to 14 years old).