TABLE 1.
Baseline characteristics of HIV-infected participants with cryptococcal meningitis or noncryptococcal meningitis and healthy control subjectsa
| Group | Cryptococcal meningitis |
Noncryptococcal meningitis |
Healthy controls |
P value | |||
|---|---|---|---|---|---|---|---|
| No. | Median (IQR) or no. (%) | No. | Median (IQR) or no. (%) | No. | Median (IQR) or no. (%) | ||
| Total no. | 31 | 12 | 10 | ||||
| Clinical parameters | |||||||
| Age (yr) | 31 | 38 (32–41) | 12 | 39 (35–45) | 8 | 39 (36.5–46.5) | 0.81 |
| Female gender | 31 | 8 (25.8) | 12 | 6 (50) | 8 | 4 (50.0) | 0.13 |
| Weight (kg) | 15 | 54 (50–58.0) | 3 | 60 (51.0–74.0) | 0.31 | ||
| CD4+ T cells/μl (normal, 800 to 1,200) | 22 | 13.5 (6–46.3) | 7 | 53.0 (7.0–279.0) | 0.3 | ||
| Currently on ART | 31 | 2 (6.5) | 12 | 0 (0.0) | |||
| Currently receiving TB therapy | 31 | 1 (3.2) | 12 | 1 (8.3) | 0.48 | ||
| Glasgow coma score of <15 | 30 | 7 (23.3) | 12 | 7 (58.3) | 0.03 | ||
| CSF parameters | |||||||
| Quantitative cryptococcal CFU/ml (log10) | 30 | 4.6 (4.1–5.3) | 12 | 0 (0–0) | |||
| Sterile cryptococcal cultures | 30 | 1 (3.3) | 12 | 12 (100.0) | |||
| Opening pressure (mm/H2O) | 25 | 259 (160–370) | 11 | 230 (128–278) | 0.32 | ||
| Opening pressure of >250 mm/H2O | 25 | 12 (48.0) | 11 | 3 (27.3) | 0.25 | ||
| Total WBC counts (cells/μl) | 28 | 17.5 (4.0–112.5) | 11 | 65 (4.0–320.0) | 0.45 | ||
| Total WBC counts of >5 (cells/μl) | 28 | 15 (53.6) | 11 | 7 (63.6) | 0.57 | ||
| CSF protein (mg/dl) | 30 | 59 (20.0–97.0) | 12 | 95.5 (43–187.0) | 0.16 | ||
a
Statistics used to generate the tabulated values were as follows: chi-square test for comparing proportions between groups, and Kruskal-Wallis test for comparing medians among groups. TB, tuberculosis; WBC, white blood cells; IQR, interquartile range.