FIG 3.

Gene expression profiles of lesion biopsy specimens from CL patients undergoing treatment with antimonials. Quantitative differences in gene expression after antimonial drug treatment in skin lesion biopsy specimens from CL patients who cured (n = 8) or did not respond to treatment (n = 8). Gene expression levels are reported as log₂(2^−ΔCt). Statistical differences were established comparing pretreatment and posttreatment samples by parametric or nonparametric univariate tests, depending on the distribution of the data. Shown are the genes that, among the 84 analyzed, showed statistically significant differences in pre- versus posttreatment samples or between patient groups. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.0001.