TABLE 2.
Genotypes and allele frequencies of SNPs in CCL2 promoter region
| SNP | Genotype or allele | Frequency (%)a
|
P valueb | Odds ratio (95% CI) | |
|---|---|---|---|---|---|
| Cured | Treatment failure | ||||
| CCL2 - rs13900 | |||||
| Genotype | CC | 9 (45) | 3 (15) | 0.082 | 4.6 (1.0–21.0) |
| TT + CT | 11 (55) | 17 (85) | |||
| Alleles | C | 27 (68) | 17 (42) | 0.042 | 2.8 (1.1–7.0) |
| T | 13 (33) | 23 (58) | |||
| CCL2 - rs2857656 | |||||
| Genotype | GG | 9 (45) | 1 (5) | 0.008 | 15.6 (1.7–139.7) |
| CC + GC | 11 (55) | 19 (95) | |||
| Alleles | G | 25 (62) | 13 (32) | 0.013 | 3.5 (1.4–8.7) |
| C | 15 (38) | 27 (68) | |||
a
Total cured patients, n = 20; total treatment failure patients, n = 20.
b
Significant associations are shown in bold italic type.