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RM-ANOVA for PCSK9. There was no statistically significant difference in PCSK9 plasma concentrations between placebo and LPS administration (P = 0.44 using the Greenhouse-Geisser correction). Time points are shown on the abscissa, and plasma concentrations of PCSK9 are shown on the ordinate (values given in nanograms per milliliter). Error bars depict 95% confidence intervals. The decrease of PCSK9 throughout the study day is due to fasting conditions and diurnal variation (26).
