Fig. 5.

Microcircuit model of tectal microcircuits during PTZ-induced epileptic seizures. (A) Coupling parameters (time constants T and coupling strengths H) of a neuronal oscillator model were fitted to calcium imaging traces during induced epileptic seizures in larval zebrafish. (B–C) parameter values at different time points are plotted on two-dimensional projection. At each point of this two-dimensional space, model parameters can be used to simulate expected features of oscillatory (shown here in for delta-band oscillatory power as background grey scale map, and gamma-band oscillatory power as isoclines). This mapping between model parameters and predicted neuronal activity identifies key changes in parameters associated with PTZ exposure and seizure activity. Similar approaches may highlight regions in parameter space that are close to state transition points and render the brain more likely to display seizure activity.

Figure reproduced with permission from Ref. [93].